Research Interests
Professor and Associate Dean for Biomedical Affairs & Research at VCOM-LC focusing on comparative genomics, bioinformatics, and One Health; head of the Integrative Genome Analysis Lab (IGAL) at the Center for One Health Research. His team has employed an integrative approach with a variety of molecular, computational, and modeling techniques, including NextGen sequencing of entire genomes, epigenomes, and transcriptomes to a rigorous understanding of how complexity elaborates from genomes through gene regulatory networks, and how it evolves over generations in response to environmental stress and intragenomic challenges. He worked in nine universities in four countries across three continents. His research resulted in a book (another is in preparation), multiple book chapters, and about 80 peer-reviewed papers in scientific journals, including “Science”, “Nature”, and “Cell”, already cited about 3,000 times and popularized by various public media.
Education
| Year | University | Degree |
|---|---|---|
| 2003 | Louisiana State University | Postdoc |
| 2002 | University of Chicago | Postdoc |
| 2000 | University of Haifa, Israel | Postdoc |
| 2000 | University of Bialystok, Poland | Postdoc |
| 1997 | Jagiellonian University, Cracow, Poland | PhD-Biology |
| 1993 | Unversity of Lodz, Poland | MS-Biology |
Selected Publications
| Year | Faculty | Citation | PMID |
|---|---|---|---|
| 2025 | Per Brolinson, Alexis Stoner, Frederic Rawlins, II, Homer Sutphin, Pawel Michalak | Brolinson PG, Stoner A, Rawlins F, Sutphin D, Michalak P. Synergizing One Health with Osteopathic Medicine: Towards a Unified Health Approach (‘One HealthOM’). BioScience. 2025 Aug 21: biaf123. doi.org/10.1093/biosci/biaf123. |
|
| 2025 | Lin Kang, Pawel Michalak | Cereghino C, Tiller K, Kang L, Michalak P, Weger-Lucarelli J. The recurrent Spike A222V mutation in SARS-CoV-2 enhances replication in primary deer lung cells. Virus Evol. 2025 Aug 5;11(1):veaf059. doi: 10.1093/ve/veaf059. eCollection 2025. PMID: 40874095. |
40874095 |
| 2025 | Pawel Michalak | Dayal Aggarwal D, Mishra P, Patel Y, Singh M, Sharma V, Korol AB, Michalak P. Experimental evolution-induced transcriptome and phenotype responses of Drosophila melanogaster to novel thermal environments. J Exp Biol. 2025 Oct 1;228(19):jeb251365. doi: 10.1242/jeb.251365. Epub 2025 Oct 10. PMID: 41058312. |
41058312 |
| 2025 | Lin Kang, Katarzyna Michalak, Robin Varghese, Ramu Anandakrishnan, Zakaria Abd Elmageed, Pawel Michalak | Kang L, Michalak K, Varghese R, Anandakrishnan R, Dick EJ Jr, Abd Elmageed Z, Michalak P. Divergent evolution of hepatocellular carcinoma genomes in chimpanzees and humans. Evol Med Public Health. 2025 Dec 15;14(1):1-14. doi: 10.1093/emph/eoaf038. eCollection 2026. PMID: 41522204. |
41522204 |
| 2025 | Pawel Michalak | Michalak P. Speciation Genomics. In De Moraes Russo CA, Wolf JB eds; Encyclopedia of Evolutionary Biology, 2nd Edition. Academic Press; October 29, 2025. . EID: 2-s2.0-105028847126. |
|
| 2021 | Lin Kang, Pawel Michalak | Kang L, He G, Sharp AK, Wang X, Brown AM, Michalak P, Weger-Lucarelli J. A selective sweep in the Spike gene has driven SARS-CoV-2 human adaptation. Cell. 2021 Aug 19;184(17):4392-4400.e4. PMID: 34289344. |
34289344 |
| 2020 | Pawel Michalak, Lin Kang | Gemmell NJ, Rutherford K, Prost S, Tollis M, Winter D, Macey JR, Adelson DL, Suh A, Bertozzi T, Grau JH, Organ C, Gardner PP, Muffato M, Patricio M, Billis K, Martin FJ, Flicek P, Petersen B, Kang L, Michalak P, Buckley TR, Wilson M, Cheng Y, Miller H, Schott RK, Jordan MD, Newcomb RD, Arroyo JI, Valenzuela N, Hore TA, Renart J, Peona V, Peart CR, Warmuth VM, Zeng L, Kortschak RD, Raison JM, Zapata VV, Wu Z, Santesmasses D, Mariotti M, Guigó R, Rupp SM, Twort VG, Dussex N, Taylor H, Abe H, Bond DM, Paterson JM, Mulcahy DG, Gonzalez VL, Barbieri CG, DeMeo DP, Pabinger S, Van Stijn T, Clarke S, Ryder O, Edwards SV, Salzberg SL, Anderson L, Nelson N, Stone C; Ngatiwai Trust Board. The tuatara genome reveals ancient features of amniote evolution. Nature. 2020 Aug;584(7821):403-409. PMID: 32760000. |
32760000 |
| 2019 | Lin Kang, Pawel Michalak, Ramu Anandakrishnan, Robin Varghese | Kinney N, Titus-Glover K, Wren JD, Varghese RT, Michalak P, Liao H, Anandakrishnan R, Pulenthiran A, Kang L, Garner HR. CAGm: a Repository of Germline Microsatellite Variations in the 1000 Genomes Project, Nucleic Acids Res. 2019 Jan 8;47(D1):D39-D45. PMID: 30329086. |
30329086 |
| 2019 | Lin Kang, Pawel Michalak, James Mahaney | Kang L, Rashkovetsky E, Michalak K, Garner HR, Mahaney JE, Rzigalinski BA, Korol A, Nevo E, Michalak P. Genomic divergence and adaptive convergence in Drosophila simulans from Evolution Canyon, Israel. Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11839-11844. PMID: 31127048. |
31127048 |
| 2017 | Lin Kang, Pawel Michalak | Yablonovitch AL, Fu J, Li K, Mahato S, Kang L, Rashkovetsky E, Korol AB, Tang H, Michalak P, Zelhof AC, Nevo E, Li JB. Regulation of gene expression and RNA editing in Drosophila adapting to divergent microclimates. Nat Commun. 2017 Nov 17;8(1):1570. PMID: 29146998. |
29146998 |
| 2014 | Katarzyna Michalak, Lin Kang, Pawel Michalak | Kim YB, Oh JH, McIver LJ, Rashkovetsky E, Michalak K, Garner HR, Kang L, Nevo E, Korol AB, Michalak P. Divergence of Drosophila melanogaster repeatomes in response to a sharp microclimate contrast in Evolution Canyon, Israel. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10630-5. PMID: 25006263. |
25006263 |
| 2013 | Katarzyna Michalak, Pawel Michalak | Hübner S, Rashkovetsky E, Kim YB, Oh JH, Michalak K, Weiner D, Korol AB, Nevo E, Michalak P. Genome differentiation of Drosophila melanogaster from a microclimate contrast in Evolution Canyon, Israel. Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21059-64. PMID: 24324170. |
24324170 |
| 2008 | Pawel Michalak | Malone JH, Michalak P. Physiological sex predicts hybrid sterility regardless of genotype. Science. 2008 Jan 4;319(5859):59. PMID: 18174434. |
18174434 |