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Blaise M. Costa, MPharm, PhD

Blaise M. Costa

Blaise M. Costa, MPharm, PhD

Associate Professor for Pharmacology
Campus: 
Virginia Campus
Office: 

CMMID 102

Department/Discipline: 
Phone: 
540-231-1468 office
540-231-6196 lab
Email: 
bcosta [at] vcom.vt.edu
Curriculum Vitae: 

After receiving a Pharmacy degree Blaise Costa (BC) pursued a theoretical biophysics research to study the structure, function and pharmacology of NMDA receptors that play a crucial role in learning and memory. For this work, he earned a PhD Degree in Psychopharmacology from The National Institute of Mental Health And Neurosciences, Bangalore India. To work out the theoretical findings, he undertook a molecular neuroscience training at the University of London. BC won the Royal Society International award to fund this training. Subsequently, as a postdoc at Max Planck Institute for Brain Research, he further studied NMDA receptor function using electrophysiology techniques. To translate this knowledge into identification of novel therapeutic agents for brain disorders, he moved to the University of Nebraska Medical Center to work on a NIH R01 funded project, for which he served as key personnel. During this work, his team discovered a novel family of negative and positive allosteric NMDA receptor modulators that remained as a challenge for about two decades. Currently, BC’s lab is interested in identifying and developing NMDA receptor based therapeutic strategy for neurodegenerative disorders with a special focus on Alzheimer’s disease.

 

Education

2009 University of Nebraska Medical Center Postdoc
2007 Max Planck Institute for Brain Research, Frankfurt, Germany Postdoc
2006 School of Pharmacy, University of London, UK International Research Fellow
2005 National Institute of Mental Health and Neurosciences, India PhD - Psychopharmacology
2001 MGR Medical University, Chennai, India MS - Pharmacology
1999 MGR Medical University, Chennai, India BPharm

Awards and Honors

  • American Heart Association, Scientist Development Grant, 2016
  • Sigma Sigma Phi VCOM Chapter, Golden Apple Award for Excellence in Teaching, 2015

Current Professional Organizations

  • Member, Society for Neuroscience
  • Member, American Heart Association and American Stroke Association
  • Member, American Society for Pharmacology and Therapeutics (ASPET)
  • Medical Pharmacology teacher, Edward Via College of Osteopathic Medicine- VA Campus

Current Research Projects

  • Development and pharmacological characterization of mechanistically distinct NMDA receptor allosteric modulators
  • Novel cranial mechanisms for improving brain metabolic waste clearance in Alzheimer’s disease
  • The efficiency and efficacy of integrated multidisciplinary learning modules that contain active learning components
  • The role of tri-heteromeric (GluN1/2/3) NMDA receptors in stroke and its mitigation

Publications

Year Published Faculty Citation PMID
2017

Bledsoe D, Tamer C, Mesic I, Madry C, Klein BG, Laube B, Costa BM. Positive Modulatory Interactions of NMDA Receptor GluN1/2B Ligand Binding Domains Attenuate Antagonists Activity. Front Pharmacol. 2017 May 9;8:229. PMID: 28536523.

28536523
2015

Kane LT, Costa BM. Identification of novel allosteric modulator binding sites in NMDA receptors: A molecular modeling study. J Mol Graph Model. 2015 Sep;61:204-213.

26280688
2015

Irvine MW, Fang G, Eaves R, Mayo-Martin MB, Costa BM, Culley GR, Volianskis A, Collingridge GL, Monaghan DT, Jane DE. Synthesis of a Series of Novel 3,9-Disubstituted Phenanthrenes as Analogues of Known N-Methyl-D-aspartate Receptor Allosteric Modulators. Synthesis. 2015 Jun 1;47(11):1593-1610.

26568642
2012

Monaghan DT, Irvine MW, Costa BM, Fang G, Jane DE. Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators. Neurochem Int. 2012 Sep;61(4):581-92. PMID: 22269804.

22269804
2012

Buch S1, Yao H, Guo M, Mori T, Mathias-Costa B, Singh V, Seth P, Wang J, Su TP. Cocaine and HIV-1 interplay in CNS: cellular and molecular mechanisms. Curr HIV Res. 2012 Jul;10(5):425-8. PMID: 22591366.

22591366
2012

Costa BM, Irvine MW, Fang G, Eaves RJ, Mayo-Martin MB, Laube B, Jane DE, Monaghan DT. Structure-activity relationships for allosteric NMDA receptor inhibitors based on 2-naphthoic acid. Neuropharmacology. 2012 Mar;62(4):1730-6. PMID: 22155206.

22155206
2012

Irvine MW, Costa BM, Dlaboga D, Culley GR, Hulse R, Scholefield CL, Atlason P, Fang G, Eaves R, Morley R, Mayo-Martin MB, Amici M, Bortolotto ZA, Donaldson L, Collingridge GL, Molnár E, Monaghan DT, Jane DE. Piperazine-2,3-dicarboxylic acid derivatives as dual antagonists of NMDA and GluK1-containing kainate receptors. J Med Chem. 2012 Jan 12;55(1):327-41. PMID: 22111545.

22111545
2012

Irvine MW, Costa BM, Volianskis A, Fang G, Ceolin L, Collingridge GL, Monaghan DT, Jane DE. Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-methyl-D-aspartate receptors. Neurochem Int. 2012 Sep;61(4):593-600. PMID: 22265875.

22265875
2013

Costa BM, Yao H, Yang L, Buch S. Role of Endoplasmic Reticulum (ER) stress in cocaine-induced microglial cell death. J Neuroimmune Pharmacol. 2013 June; 8(3):704-14. PMID: 23404095.

23404095
2013

Gautam V, Trinidad JC, Rimerman RA, Costa BM, Burlingame AL, Monaghan DT. Nedd4 is a specific E3 ubiquitin ligase for the NMDA receptor subunit GluN2D. Neuropharmacology. 2013 Nov; 74:96-107. PMID: 23639431.

23639431
2013

Collingridge GL, Volianskis A, Bannister N, France G, Hanna L, Mercier M, Tidball P, Fang G, Irvine MW, Costa BM, Monaghan DT, Bortolotto ZA, Molnár E, Lodge D, Jane DE. The NMDA receptor as a target for cognitive enhancement. Neuropharmacology. 2013 Jan; 64:13-26. PMID: 22796429.

22796429