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J. Danielle Danielle McCullough, MS, PhD

Portrait of Jillian McCullough
J. Danielle McCullough, MS, PhD
Associate Dean for Curriculum, Assessment & Medical Education
Department/Discipline: Medical Education
Campus: Auburn
Office: 217
Preferred First Name: J. Danielle
Fax: 334-442-4096
Email: Contact

Education

Year University Degree
2015 Brown University/Providence VA Medical Center Postdoctoral Fellow - Cardiopulmonary Physiology & Vascular Research Laboratory
2013 University of Florida PhD - Exercise Physiology
2009 University of Florida MS - Human Performance
2007 University of Guelph BS - Human Kinetics/Sports Injury Management

Research Interests

My primary research interests are in the field of cardiovascular physiology and, in particular, the effects of exercise on microvascular function and hemodynamic control in the setting of various physiological stressors and pathologies. Ultimately, my research goals are to i) elucidate mechanisms associated with exercise-induced improvements in vascular function and blood flow control in common pathologies (heart failure, prostate cancer, and pulmonary hypertension), and ii) promote the use of exercise as a therapeutic modality in the management and prevention of disease progression in rodent pre-clinical models of disease.

Selected Publications

Year Faculty Citation PMID
2020 Jillian McCullough

McCullough DJ, Kue N, Mancini T, Vang A, Clements RT, Choudhary G. Endurance Exercise Training in Pulmonary Hypertension Increases Skeletal Muscle Electron Transport Chain Supercomplex Assembly. Pulm Circ. 2020 May 18;10(2): 2045894020925762. PMID: 32523689.

32523689
2019 Jillian McCullough

Clements RT, Vang A, Fernandez-Nicolas A, Kue NR, Mancini TJ, Morrison AR, Mallem K, McCullough DJ, Choudhary G. Treatment of Pulmonary Hypertension With Angiotensin II Receptor Blocker and Neprilysin Inhibitor Sacubitril/Valsartan. Circ Heart Fail. 2019 Nov;12(11):e005819. PMID: 31707802.

31707802
2019 Jillian McCullough

Roberson PA, Romero MA, Osburn SC, Mumford PW, Vann CG, Fox CD, McCullough DJ, Brown MD, Roberts MD. Skeletal muscle LINE-1 ORF1 mRNA is higher in older humans but decreases with endurance exercise and is negatively associated with higher physical activity. J Appl Physiol (1985). 2019 Oct 1;127(4):895-904.  PMID: 31369326.

31369326
2019 Jillian McCullough

Horn AG, Davis RT 3rd, Baumfalk DR, Kunkel ON, Bruells CS, McCullough DJ, Opoku-Acheampong AB, Poole DC, Behnke BJ. Impaired diaphragm resistance vessel vasodilation with prolonged mechanical ventilation. J Appl Physiol (1985). 2019 Aug 1;127(2):423-431. PMID: 31161883.

31161883
2016 Jillian McCullough

Garcia E, Becker VG, McCullough DJ, Stabley JN, Gittemeier EM, Opoku-Acheampong AB, Sieman DW, Behnke BJ. Blood flow responses to mild-intensity exercise in ectopic vs. orthotopic prostate tumors; dependence upon host tissue hemodynamics and vascular reactivity. J Appl Physiol (1985). 2016 Jul 1;121(1):15-24.

27125846
2016 Jillian McCullough

Holland AM, Kephart WC, Mumford PW, Mobley CB, Lowery RP, Shake JJ, Patel RK, Healy JC, McCullough DJ, Kluess HA, Huggins KW, Kavazis AN, Wilson JM, Roberts MD. Effects of a ketogenic diet on adipose tissue, liver and serum biomarkers in sedentary rats and rats that exercised via resisted voluntary wheel running. Am J Physiol Regul Integr Comp Physiol. 2016 Jun 29:ajpregu.00156.2016.

27357802
2016 Jillian McCullough

Prisby RD, Alwood JS, Behnke BJ, Stabley JN, McCullough DJ, Ghosh P, Globus RK, Delp MD. Effects of hindlimb unloading and ionizing radiation on skeletal muscle resistance artery vasodilation and its relation to cancellous bone in mice. J Appl Physiol (1985). 2016 Jan 15;120(2):97-106.

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2016 Jillian McCullough

Garcia E, Becker VGC, Gittemeier EM, Opoku-Acheampong AB, McCullough DJ, Behnke BJ. Orthotopic versus ectopic tumor perfusion during exercise: implications for host tissue vasoreactivity. FASEB J. 2016 Apr;30:763.23.

2015 Jillian McCullough

Sofronova SI, Tarasova OS, Gaynullina D, Borzykh AA, Behnke BJ, Stabley JN, McCullough DJ, Maraj JJ, Hanna M, Muller-Delp JM, Vinogradova OL, Delp MD. Spaceflight on the Bion-M1 biosatellite alters cerebral artery vasomotor and mechanical properties in mice. J Appl Physiol (1985). 2015 Apr 1;118(7):830-8.

25593287
2014 Jillian McCullough

Hirai DM, Copp SW, Holdsworth CT, Ferguson SK, McCullough DJ, Behnke BJ, Musch TI, Poole DC. Skeletal muscle microvascular oxygenation dynamics in heart failure: exercise training and nitric oxide-mediated function. Am J Physiol Heart Circ Physiol. 2014 Mar 1;306(5):H690-8.

24414070
2014 Jillian McCullough

McCullough DJ, Stabley JN, Siemann DW, Behnke BJ. Modulation of blood flow, hypoxia, and vascular function in orthotopic prostate tumors during exercise. J Natl Cancer Inst. 2014 Apr;106(4):dju036.

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2014 Jillian McCullough

McCullough DJ, Vang A, Choudhary G. NS1619-induced vasodilation is enhanced and differentially mediated in chronically hypoxic lungs. Lung. 2014 Oct;192(5):811-7.

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2013 Jillian McCullough

Taylor CR, Hanna M, Behnke BJ, Stabley JN, McCullough DJ, Davis RT III, Ghosh P, Papadopoulos A, Muller-Delp JM, Delp MD. Spaceflight-induced alterations in cerebral artery vasoconstrictor, mechanical, and structural properties: implications for elevated cerebral perfusion and intracranial pressure. FASEB J. 2013 Jun;27(6):2282-92.

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2013 Jillian McCullough

McCullough DJ, Nguyen LM, Siemann DW, Behnke BJ. Effects of exercise training on tumor hypoxia and vascular function in the rodent pre-clinical orthotopic prostate cancer model. J Appl Physiol. 2013 Dec;115(12):1846-54.

24177690
2013 Jillian McCullough

McCullough DJ, Siemann DW, Behnke BJ. Role of vascular dysfunction in prostate tumor perfusion during exercise. FASEB J. 2013 Apr;27:1136.15.

2013 Jillian McCullough

Behnke BJ, Stabley JN, Ramsey MW, McCullough DJ, Dominguez JM, Lesniewski LA, Davis RT, Delp MD. Differential effects of aging and exercise training on intra-abdominal adipose arteriolar function and blood flow regulation. FASEB J. 2013 Apr;27: 898.6.

2013 Jillian McCullough

Behnke BJ, Stabley JN, McCullough DJ, Davis RT III, Dominguez JM II, Muller-Delp JM, Delp MD. Effects of spaceflight and ground recovery on mesenteric artery and vein constrictor properties in mice. FASEB J. 2013 Jan; 27(1):399-409.

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2013 Jillian McCullough

Davis RT III, Stabley JN, Dominguez JM II, Ramsey MW, McCullough DJ, Lesniewski LA, Delp MD, Behnke BJ. Differential effects of aging and exercise on intra-abdominal adipose arteriolar function and blood flow regulation. J Appl Physiol. 2013 Mar 15;114(6):808-15.

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2012 Jillian McCullough

Hanna M, Stabley JN, McCullough DJ, Dominguez JM, Muller-Delp JM, Behnke BJ, Taylor CR, Delp MD. Effects of spaceflight on vasoconstrictor and mechanical properties of mouse cerebral arteries. FASEB J. 2012 Apr;26:lb660.

2012 Jillian McCullough

Davis RT, Bruells CS, Stabley JN, McCullough DJ, Powers SK, Behnke BJ. Mechanical ventilation induces a time-dependent reduction in microvascular oxygenation and vascular conductance in the diaphragm. FASEB J. 2012 Apr;26:860.20.

2012 Jillian McCullough

McCullough DJ, Stabley JN, Davis RT, Siemann DW, Behnke BJ. Acute exercise increases prostate tumor blood flow in rats. FASEB J. 2012 Apr;26:1138.36.

2012 Jillian McCullough

Hirai DM, Copp SW, Ferguson SK, Holdsworth CT, McCullough DJ, Behnke BJ, Musch TI, Poole DC. Exercise training and muscle microvascular oxygenation: functional role of nitric oxide. J Appl Physiol. 2012 Aug 15; 113(4):557-65.

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2012 Jillian McCullough

Behnke BJ, Ramsey MW, Stabley JN, Dominguez JM II, Davis RT III, McCullough DJ, Muller-Delp JM, Delp MD. Effects of aging and exercise training on skeletal muscle blood flow and resistance artery morphology. J Appl Physiol. 2012 Dec 1;113(11):1699-708.

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2011 Jillian McCullough

Behnke BJ, Davis RT, Ma X, McCullough DJ, Dominguez JM, Delp MD. Effects of aging on purinergic vasoconstriction in skeletal muscle arterioles. FASEB J. 2011 Apr;25:635.7.

2011 Jillian McCullough

McCullough DJ, Davis RT III, Dominguez JM II, Stabley JN, Bruells CS, Behnke BJ. Effects of aging and exercise training on spinotrapezius muscle microvascular PO2 dynamics and vasomotor control. J Appl Physiol. 2011 Mar; 110(3):695-704.

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2011 Jillian McCullough

Dominguez JM II, Davis RT III, McCullough DJ, Stabley JN, Behnke BJ. Aging and exercise training reduce testes microvascular PO2 and alter vasoconstrictor responsiveness in testicular arterioles. Am J Physiol Regul Integr Comp Physiol. 2011 Sep; 301(3):R801-10.

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2010 Jillian McCullough

McCullough DJ, Davis RT, Delp MD, Behnke BJ. Effects of aging on vasoconstrictor dynamics in soleus resistance arteries. Medicine & Science in Sports & Exercise. 2010 May;42(5):123.

2010 Jillian McCullough

McCullough DJ, Davis RT III, Behnke BJ. Effects of aging and exercise training on spinotrapezius muscle microvascular PO2. Medicine & Science in Sports & Exercise. 2010 Oct;42(10):2.

2010 Jillian McCullough

Davis RT III, McCullough DJ, Dominguez JM II, Behnke BJ. Effects of aging and exercise training on alpha-adrenergic vasomotor responses of rat adipose tissue arterioles. Medicine & Science in Sports & Exercise. 2010 Oct;42(10):00.

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