Current research focus is on regulatory mechanisms of skeletal and cardiac muscle adaptation. Muscle atrophy and contractile and metabolic adaptations occur in skeletal muscle in response to inactivity and various disease states. Similar changes occur in heart muscle in response to disease states such as hypertension, which can result in compensatory hypertrophy and ultimately heart failure. My laboratory has identified several novel long-non coding (lnc) RNAs that are implicated in gene regulation, particularly those of the myosin heavy chain gene family of motor proteins. These lncRNAs may serve as feasible therapeutic targets to restore muscle function compromised by disuse or disease.
- American Physiological Society, Member
Pandorf C, Haddad F, Owerkowicz T, Carroll L, Baldwin K, Adams GR. Regulation of Myosin Heavy Chain Antisense Long Noncoding RNA in Human Vastus Lateralis in Response to Exercise Training. AJP-Cell Physiology. Am J Physiol. 2020 May 1;318(5):C931-C942. PMID: 32130073.