Stephan Brown, MD, PhD

My research interests include determining the effects of endocrine disrupting chemicals on developing tissues. To date, we have determined tolylfluanid decreases oxygen consumption in heart and muscle cells, which increases metabolic demand and mitochondrial biogenesis. I also have an ongoing project with the aim of understanding the colon cancer development in inflammatory bowel disease (IBD). We have determined that IBD impedes colon crypt development, which increases the likelihood of cancer development. These current projects are in calibration with researchers and students from VCOM Carolinas, USC Upstate and Virginia-Maryland College of Veterinary Medicine. Involvement of students is an intrinsically gratifying aspect of my research program. Though these interests may seem completely different, they allow me to develop cell models to answer dynamic biological questions. My goal is to obtain federal funding to pursue further studies to contribute to the body of knowledge in the aforementioned areas as well as health and education for diverse populations. My laboratory capabilities include cellular signaling determination, protein isolation and function assays, stem cell culturing and reprogramming, cancer biology, and metabolomics.