Skip received his BS in Nuclear Engineering at the University of Missouri - Rolla in 1976. Skip received a Ph.D. in plasma physics from the University of Wisconsin, Madison in 1982. He also holds an honorary professional engineering degree.
Skip worked for 12 years at General Atomics in La Jolla, California, where he conducted experimental and theoretical research for the Department of Energy at international fusion research facilities. In the last 6 years at General Atomics, he was a founding member of “The Institute”, an internal think tank, where he developed artificial intelligence/expert systems, new particle accelerators, high temperature superconductors, stealth/defense technologies and biology software and instrumentation.
From 1994 to 2009, at the University of Texas Southwestern Medical Center, Skip held the P. O’B. Montgomery, M.D., Distinguished Chair, was a Professor of Biochemistry and Internal Medicine and a founding member of the Division of Translational Research (DTR).
In 2009, Skip moved to Virginia Tech, where he is currently the Executive Director, office of Medical Informatics, Translation, Training and Ethics (MITTE) and a professor of biological science, computer science and medicine.
In 2016, Skip also became a Professor of Biomedicine, Edward Via College of Osteopathic Medicine (VCOM) and Executive Director, Primary Care Research Network and the Center for Bioinformatics and Genetics.
He sits on numerous corporate advisory boards and advises for numerous governmental agencies. He is also the founder of several companies - Helix, BioAutomation, Light Biology (sold to Nimblegen, acquired by Roche), Orbit Genomics, Heliotext, Quanta Lingua and Comperity.
Skip has published over 200 peer-reviewed manuscripts, 10 books/book chapters and has over 30 issued and pending patents, US and International.
Education
| Year | University | Degree |
|---|---|---|
| 1994 | University of Missouri, Rolla | PE - Nuclear Engineering (honorary) |
| 1982 | University of Wisconsin, Madison | PhD - Plasma Physics |
| 1978 | University of Wisconsin, Madison | MS - Nuclear Engineering |
| 1976 | University of Missouri, Rolla | BS - Nuclear Engineering |
Research Interests
My research interests include: 1) development of computational biology and bioinformatics solutions for genetics, genomics, other-“omics”, 2) biomarker and drug target discovery in complex multi-genic disorders (cancer, heart disease, neurological disease), 3) text analytics and publication and medical ethics, 4) High Performance Computing especially scalable diversified systems, 5) new approaches to medical education including software, medical school/GME/CME instruction, case-based learning, online learning, 6) translating findings into clinical diagnostics and therapeutics.
My research capabilities include: genomics, human genetics, genetic basis of disease, computer science, programming, web development, physics, engineering, medical instruction, research design, scientific writing, ethics, futurism, business, entrepreneurship, student research mentorship.
Awards
- Fellow of the American Institute for Medical and Biological Engineering
- Charter member of the Academy of the School of Mines and Metallurgy and Order of the Golden Shillelagh, University of Missouri - Rolla
- Postdoctoral Mentor of the Year, UT Southwestern Medical Center 2008
- Fellow of the Virginia Tech Honors Residence College
Activities
- AAAS, AACR, VaBio
Selected Publications
| Year | Faculty | Citation | PMID |
|---|---|---|---|
| 2021 | Lin Kang, Ramu Anandakrishnan, Harold "Skip" Garner | Kinney N, Kang L, Bains H, Lawson E, Husain M, Husain K, Sandhu I, Shin Y, Carter JK, Anandakrishnan R, Michalak P, Garner H. Ethnically biased microsatellites contribute to differential gene expression and glutathione metabolism in Africans and Europeans. PLoS One. 2021 Mar 25;16(3):e0249148. doi: 10.1371/journal.pone.0249148. eCollection 2021. PMID: 33765058. |
33765058 |
| 2021 | Ramu Anandakrishnan, Harold "Skip" Garner | Dash S, Al-Hajri Q, Feng W-C, Garner HR, Anandakrishnan R. Scaling Out a Combinatorial Algorithm for Discovering Carcinogenic Gene Combinations to Thousands of GPUs. In 2021 IEEE International Parallel and Distributed Processing Symposium (IPDPS), pp. 837-846. IEEE, 2021. https://ieeexplore.ieee.org/abstract/document/9460537, DOI: 10.1109/IPDPS49936.2021.00093 |
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| 2020 | Ramu Anandakrishnan, Harold "Skip" Garner | Al Hajri Q, Dash S, Feng WC, Garner HR, Anandakrishnan R.Identifying multi-hit carcinogenic gene combinations: Scaling up a weighted set cover algorithm using compressed binary matrix representation on a GPU. Sci Rep. 2020 Feb 6;10(1):2002. PMID: 32029803. |
32029803 |
| 2020 | Harold "Skip" Garner | Fan B, Fan W, Smith C, Garner HR. Adverse drug event detection and extraction from open data: A deep learning approach. Information Processing and Management. 2020 Jan;57(1):102131. https://doi.org/10.1016/j.ipm.2019.102131. |
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| 2020 | Ramu Anandakrishnan, Harold "Skip" Garner | Kinney N, Hickman M, Anandakrishnan R, Garner HR. Crossing complexity of space-filling curves reveals entanglement of S-phase DNA. PLoS One. 2020 Aug 31;15(8):e0238322. PMID: 32866178.
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32866178 |
| 2020 | Ramu Anandakrishnan, Tiffany Carpenetti, Lin Kang, Arben Santo, Harold "Skip" Garner, Robin Varghese | Anandakrishnan R, Carpenetti TL, Samuel P, Wasko B, Johnson C, Smith C, Kim J, Michalak P, Kang L, Kinney N, Santo A, Anstrom J, Garner HR, Varghese RT. DNA sequencing of anatomy lab cadavers to provide hands-on precision medicine introduction to medical students. BMC Med Educ. 2020 Nov 16;20(1):437. PMID: 33198737. |
33198737 |
| 2020 | Harold "Skip" Garner | Rivero-Hinojosa S, Kinney N, Garner HR, Rood BR. Germline microsatellite genotypes differentiate children with medulloblastoma. Neuro Oncol. 2020 Jan 11;22(1):152-162. PMID: 31562520. |
31562520 |
| 2019 | Lin Kang, Pawel Michalak, Ramu Anandakrishnan, Robin Varghese, Harold "Skip" Garner | Kinney N, Titus-Glover K, Wren JD, Varghese RT, Michalak P, Liao H, Anandakrishnan R, Pulenthiran A, Kang L, Garner HR. CAGm: a Repository of Germline Microsatellite Variations in the 1000 Genomes Project, Nucleic Acids Res. 2019 Jan 8;47(D1):D39-D45. PMID: 30329086. |
30329086 |
| 2019 | Ramu Anandakrishnan, Robin Varghese, Harold "Skip" Garner | Dash S, Kinney N, Varghese R, Garner H, Feng W, Anandakrishnan R. Differentiating between cancer and normal tissue samples using multi-hit combinations of genetic mutations. Sci Rep. 2019 Jan 30;9(1):1005. PMID: 30700767. |
30700767 |
| 2019 | Ramu Anandakrishnan, Robin Varghese, Harold "Skip" Garner | Anandakrishnan R, Varghese R, Kinney N, Garner HR. Estimating the number of genetic mutations (hits) required for tumorigenesis based on the distribution of somatic mutations. PLoS Comput Biol. 2019 Mar 7;15(3):e1006881. PMID: 30845172. |
30845172 |
| 2019 | Lin Kang, Pawel Michalak, Harold "Skip" Garner, James Mahaney | Kang L, Rashkovetsky E, Michalak K, Garner HR, Mahaney JE, Rzigalinski BA, Korol A, Nevo E, Michalak P. Genomic divergence and adaptive convergence in Drosophila simulans from Evolution Canyon, Israel. Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11839-11844. PMID: 31127048. |
31127048 |
| 2019 | Harold "Skip" Garner | Rivero-Hinojosa S, Kinney N, Garner HR, Rood BR. Germline Microsatellite Genotypes Differentiate Children with Medulloblastoma. Neuro Oncol. 2019 Sep 28. pii: noz179. [Epub ahead of print]. PMID: 31562520. |
31562520 |
| 2019 | Lin Kang, Ramu Anandakrishnan, Robin Varghese, Harold "Skip" Garner | Kinney N, Kang L, Eckstrand L, Pulenthiran A, Samuel P, Anandakrishnan R, Varghese RT, Michalak P, Garner HR. Abundance of ethnically biased microsatellites in human gene regions. PLoS One. 2019 Dec 12;14(12):e0225216. PMID: 31830051. |
31830051 |
| 2019 | Cameron Sumpter, Harold "Skip" Garner, Frederic Rawlins, II | Stanco KM, Prater MR, Wubah A, Sumpter C, Rawlins F, Garner HR. Improving Medical Education by Coupling Basic Science Lectures and Clinical Rotations via ICD Codes. J Am Osteopath Assoc. 2019 Apr 1;119(4):251-256. PMID: 30907964. |
30907964 |
| 2018 | Lin Kang, Harold "Skip" Garner | Velmurugan KR, Michalak P, Kang L, Fonville NC, Garner HR. Dysfunctional DNA repair pathway via defective FANCD2 gene engenders multifarious exomic and transcriptomic effects in Fanconi anemia. Mol Genet Genomic Med. 2018 Nov;6(6):1199-1208. PMID: 30450770. |
30450770 |
| 2018 | Lin Kang, Harold "Skip" Garner | Michalak P, Kang L, Schou MF, Garner HR, Loeschcke V. Genomic signatures of experimental adaptive radiation in Drosophila. Mol Ecol. 2019 Feb;28(3):600-614. PMID: 30375065. |
30375065 |
| 2018 | Cameron Sumpter, Harold "Skip" Garner, Homer Sutphin, Frederic Rawlins, II | Wubah AA, Yankson JA, Sumpter C, Rawlins F, Sutphin D, Menier K, Garner HR. Evaluation of an ICD Logging System to Supplement an EMR in a Sub-Saharan Country. Journal of Hospital Administration, 2018;7(2). |
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| 2018 | Robin Varghese, Harold "Skip" Garner | Kinney N, Larsen TR, Kim DM, Varghese RT, Poelzing S, Garner HR, AlMahameed ST. Whole Exome Sequencing Reveals Microsatellites DNA Markers for Response to Dofetilide Initiation in Patients with Persistent Atrial Fibrillation, A Pilot Study. Clin Cardiol. 2018 Apr 19. PMID: 29671888. |
29671888 |
| 2017 | Harold "Skip" Garner | Kang L, Garner HR, Price DK, Michalak P. A Test for Gene Flow among Sympatric and Allopatric Hawaiian Picture-Winged Drosophila. J Mol Evol. 2017 Jun;84(5-6):259-66. PMID: 28492967. |
28492967 |
| 2017 | Robin Varghese, Harold "Skip" Garner | Velmurugan KR, Varghese RT, Fonville NC, Garner HR. High-depth, high-accuracy microsatellite genotyping enables precision lung cancer risk classification. Oncogene. 2017 Jul 31. Epub ahead of print. PMID: 28759038. |
28759038 |
| 2017 | Ramu Anandakrishnan, Robin Varghese, Harold "Skip" Garner | Kinney N, Varghese RT, Anandakrishnan R, Garner HR. ZDHHC3 as a risk and mortality marker for breast cancer in African American Women. Cancer Informatics. 2017;16:1–6. PMID: 29276372. |
29276372 |
| 2017 | Cameron Sumpter, Harold "Skip" Garner, Homer Sutphin, Frederic Rawlins, II | Rawlins F, Sumpter C, Sutphin D, Garner HR, Quantifying medical student clinical experiences via an ICD Code Logging App. Int J Med Inform. 2018 Mar;111:51-57. PMID: 29425634. |
29425634 |
| 2016 | Harold "Skip" Garner | Fonville NC, Velmurugan KR, Tae H, Vaksman Z, McIver LJ, Garner HR. Genomic leftovers: identifying novel microsatellites, over-represented motifs and functional elements in the human genome. Nature Sci Rep. 2016 Jun 9;6:27722. |
27278669 |
| 2016 | Harold "Skip" Garner | Patidar PL, Motea EA, Fattah FJ, Zhou Y, Morales JC, Xie Y, Garner HR, Boothman DA. The Kub5-Hera/RPRD1B interactome: A novel role in preserving genetic stability by regulating DNA mismatch repair. Nucleic Acids Res. 2016 Feb 29;44(4):1718-31. |
26819409 |
| 2016 | Harold "Skip" Garner | Kang L, Settlage R, McMahon W, Michalak K, Tae H, Garner HR, Stacy EA, Price DK, Michalak P. Genomic signatures of speciation in sympatric and allopatric Hawaiian picture-winged Drosophila. Genome Biol Evol. 2016 May 30;8(5):1482-8. |
27189993 |
| 2015 | Harold "Skip" Garner | Michalak K, Maciak S, Kim YB, Santopietro G, Oh JH, Kang L, Garner HR, Michalak P. Nucleolar dominance and maternal control of 455 rDNA expression. Proc Biol Sci. 2015 Dec 7;282(1820):20152201. |
26645200 |
| 2014 | Katarzyna Michalak, Harold "Skip" Garner, Lin Kang, Pawel Michalak | Kim YB, Oh JH, McIver LJ, Rashkovetsky E, Michalak K, Garner HR, Kang L, Nevo E, Korol AB, Michalak P. Divergence of Drosophila melanogaster repeatomes in response to a sharp microclimate contrast in Evolution Canyon, Israel. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10630-5. PMID: 25006263. |
25006263 |