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Jillian H. Bradley, PhD

Jillian H. Bradley

Jillian H. Bradley, PhD

Assistant Professor for Microbiology and Immunology
Campus: 
Carolinas Campus
Office: 

Magnolia Research Center, Office 202

Department/Discipline: 
Phone: 
864-327-9815
Email: 
jhbradley [at] carolinas.vcom.edu
Curriculum Vitae: 

Dr. Bradley completed her graduate thesis at Augusta University in Augusta, GA in 2015. Her thesis project was on the polarization of macrophages during helminth infection. She was co-author of five publications during this time.

 

Dr. Bradley came to VCOM in July 2015 as a Post-Doctoral Research Fellow, and has since become involved in multiple projects in the Magnolia Research Center. One of the projects are learning about the effects of Ebola virus proteins on non-infected immune cells. The lab is also exploring whether the different Ebola strains have different effects on immune cells, which might correlate with the discrepancy in mortality between the different strains. Her main Post-Doctoral project was exploring the effect of Ebola virus glycoprotein on macrophage differentiation, polarization, and function. This work has the potential to greatly affect vaccine design strategies, as well as potentially lead to a specific treatment for acutely infected patients. During this time, she published a first-author publication on how surviving in space can affect the immune function of cells.

She is currently also exploring the role of Facial Effleurage maneuvers, an Osteopathic Manipulative Therapy, on acute rhinosinusitis. Her lab is looking into the immunological and microbial parameters and symptom resolution to see if Facial Effleurage can affect the symptom severity and/or duration.

Education

2015 - Present Edward Via College of Osteopathic Medicine - Carolinas Campus Post-Doctoral Research Fellow
2015 Augusta University PhD - Biomedical Sciences
2010 Armstrong State University BS - Biology

Awards and Honors

  • American Association of Immunologists, Trainee Abstract Award, 2014
  • Graduate Research Day at GRU, Excellence in Research Award, 2014
  • VCOM Research Recognition Day, 1st, 2nd, 3rd Place Biomedical Poster Presentation Awards, 2017
  • VCOM Research Recognition Day, 1st, 2nd, 3rd Place Biomedical Oral Presentation Awards, 2017
  • VCOM Research Recognition Day, 1st Place Undergraduate Poster Presentation Award, 2017
  • Student's Choice, Professor of the Block, 2016

Current Professional Organizations

  • Member, International Society of Infectious Disease
  • Member, American Association of Immunologists
  • Member, American Society of Microbiology

Current Research Projects

  • Creating a Professional Learning Community within Osteopathic Medical Students to foster a positive environment for peer-to-peer learning to improve retention rates
  • Determining the mechanism behind the modulatory effects of sGP on macrophage and dendritic cell functions
  • Effect of Ebola virus proteins, VP40 and secreted glycoprotein, upon macrophage differentiation, polarization and function
  • The effect of Ebola virus proteins on T helper cell cytokine production
  • The effect of Ebola virus proteins, VP40 and sGP, on dendritic cells cytokine production, antigen presentation and T-cell activation
  • The effect of facial effleurage on acute rhinosinusitis

Publications

Year Published Faculty Citation PMID
2015

Chaudhary K, Shinde R, Liu H, Gnana-Prakasam JP, Veeranan-Karmegam R, Huang L, Ravishankar B, Bradley J, Kvirkvelia N, McManamin M, Xiao W, Kleven D, Mellor AL, Madaio MP, McGaha TL. Amino acid metabolism inhibits antibody-driven kidney injury by inducing autophagy. J Immunol. 2015 Jun 15;194(12):5713-24.

25980011
2015

Ravishankar B, Liu H, Shinde R, Chaudhary K, Xiao W, Bradley J, Koritzinsky M, Madaio M, McGaha TL. The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity. Proc Natl Acad Sci USA. 2015 Aug 25;112(34):10774-9.

26261340
2015

Shinde R, Shimoda M, Chaudhary K, Liu H, Mohamed E, Bradley J, Kandala S, Li X, Liu K, McGaha TL. B cell-intrinsic IDO1 regulates humoral immunity to T-cell-independent antigens. J Immunol. 2015 Sep 1;195(5):2374-82.

26216892
2014
Ravishankar B, Shinde R, Liu H, Chaudhary K, Bradley J, Lemos HP, Chandler P, Tanaka M, Munn DH, Mellor AL, McGaha TL. Marginal zone CD169+ macrophages coordinate apoptotic cell-driven cellular recruitment and tolerance. Proc Natl Acad Sci USA. 2014 Mar 18;111(11):4215-20. PMID: 24591636.
24591636
2014

Liu H, Huang L, Bradley J, Liu K, Bardhan K, Ron D, Mellor AL, Munn DH, McGaha TL.GCN2-dependent metabolic stress is essential for endotoxemic cytokine induction and pathology. Mol Cell Biol. 2014 Feb;34(3):428-38. PMID: 24248597.

24248597