Menu
Mobile menu

Chris Reilly, PhD

Christopher M. Reilly

Chris Reilly, PhD

Discipline Chair for Cellular Biology and Physiology
Campus: 
Virginia Campus
Office: 

351

Department/Discipline: 
Phone: 
540-231-5345
Fax: 
540-231-5338
Email: 
chreilly [at] vcom.vt.edu
Curriculum Vitae: 
 

Education

2000 MUSC Charleston  Postdoc
1997 Medical College of Georgia PhD-Physiology/Endocrinology 
1991 University of New Mexico BS-Biology
 

Awards and Honors

  • Grant funding from Acetylon Pharmaceuticals for the proposal, “Inhibition of SLE with the HDAC6 inhibitor ACY-1083 in NZB/W female mice.” The grant was funded in February 2014 and the award is for $240,253
  • Featured in the Microsoft Cloud article that accompanies their commercial that is currently airing on television. http://news.microsoft.com/features/cloud-computing-contributes-to-individually-tailored-medical-treatments-of-the-future/
  • Reviewer for AOA abstracts for national meeting
  • Reviewer for AOA grant awards

Current Research Projects

  • Early growth response protein 2 (EGR2)-mediated epigenetic regulatory network in lupus

Publications

Year Published Faculty Citation PMID
2017

Liao X, Ren J, Reihl A, Pirapakaran T, Sreekumar B, Cecere TE, Reilly CM, Luo XM. Renal-infiltrating CD11c+ cells are pathogenic in murine lupus nephritis through promoting CD4+ T cell responses. Clin Exp Immunol. 2017 Jul 19: Epub ahead of print. PMID: 28722110.

28722110
2017

Mu Q, Zhang H, Liao X, Lin K, Liu H, Edwards MR, Ahmed SA, Yuan R, Li L, Cecere TE, Branson DB, Kirby JL, Goswami P, Leeth CM, Read KA, Oestreich KJ, Vieson MD, Reilly CM, Luo XM.  Control of lupus nephritis by changes of gut microbiota. Microbiome. 2017 Jul 11;51(1):73.

28697806
2017

Mu Q, Kirby J, Reilly CM, Luo XM. Leaky Gut As a Danger Signal for Autoimmune Diseases. Front Immunol. 2017 May 23;8:598. PMID: 28588585.

 
28588585
2017

Vieson MD, Gojmerac AM, Khan D, Dai R, van Duzer JH, Mazitschek R, Caudell DL, Liao X, Luo XM, Reilly CM. Treatment with a selective histone deacetylase 6 inhibitor decreases lupus nephritis in NZB/W mice. Histol Histopathol. 2017 Feb 28:11885. PMID: 28245046.

28245046
2016

Regna NL, Vieson MD, Luo XM, Chafin CB, Puthiyaveetil AG, Hammond SE, Caudell DL, Jarpe MB, Reilly CM.  Specific HDAC6 inhibition by ACY-738 reduces SLE pathogenesis in NZB/W mice.  Clin Immunol. 2016 Jan;162:58-73.

26604012
2015

Liao X, Li S, Settlage RE, Sun S, Ren J, Reihl AM, Zhang H, Karyala SV, Reilly CM, Ahmed SA, Luo XM. Cutting Edge: Plasmacytoid Dendritic Cells in Late-Stage Lupus Mice Defective in Producing IFN-α. J Immunol. 2015 Nov 15;195(10):4578-82.

 

26447229
2015

Parson C, Smith V, Krauss C, Banerjee HN, Reilly C, Krause JA, Wachira JM, Giri D, Winstead A, Mandal SK. Anticancer Properties of Novel Rhenium Pentylcarbanato Compounds against MDA-MB-468(HTB-132) Triple Node Negative Human Breast Cancer Cell Lines.  Br J Pharm Res. 2015 Feb 1;4(3):362-367

25419517
2015

Regna NL, Vieson MD, Gojmerac AM, Luo XM, Caudell DL, Reilly CM.  HDAC expression and activity is upregulated in diseased lupus-prone mice.  Int Immunopharmacol. 2015 Dec;29(2):494-503.

26471208
2014

Regna NL, Reilly CM. Isoform-selective HDAC inhibition in autoimmune disease [review]. Journal of Clinical & Cellular Immunology. 2014 April; 5:207. doi: 10.4172/2155-9899.1000207.

2014

Regna LN, Chafin CB, Hammond SE, Puthiyaveetil AG, Caudell, DL, Reilly CM. Class I and II histone deacetylase inhibition by ITF2357 reduces SLE pathogenesis In vivo. Clinical Immunology. 2014 Mar; 151(1):29-42.

24503172
2014

Chafin CB, Regna NL, Caudell DL, Reilly CM. MicroRNA-let-7a promotes E2F-mediated cell proliferation and NF?B activation in vitro. Cell Mol Immunol. 2014 Jan; 11(1):79-83.

24240124
2013

Bandara AB, Boyle SM, Contreras-Rodriguez A, Martins AM, Prasad R, Reilly CM, Brucella melitensis differs from B. suis in growth and urease activity in-vitro, and infectivity in Fisher-344 Rats in-vivo. Advances in Infectious Diseases. 2013; 3(1):60-2. doi: 10.4236/aid.2013.31008.

2013

Chafin CB, Regna NL, Hammond SE, Caudell DL, Reilly CM. Cellular and urinary microRNA alterations in NZB/W mice with hydroxychloroquine or prednisone treatment. Int Immunopharmacol. 2013 Nov; 17(3):894-906.

24121037
2013

Giri S, Karakoti A, Graham RP, Maguire JL, Reilly CM, Seal S, Rattan R, Shridhar V. Nanoceria: a rare-earth nanoparticle as a novel anti-angiogenic therapeutic agent in ovarian cancer. PLoS One. 2013; 8(1):e54578.

23382918
2011

Alili L, Sack M, Karakoti AS, Teuber S, Puschmann K, Hirst SM, Reilly CM, Zanger K, Stahl W, Seal S, Brenneisen P. Combined cytotoxic and anti-invasive properties of redoxactive nanoparticles in tumor-stroma interactions. Biomaterials. 2011 Apr; 32(11): 2918-29.

21269688
2010

Chafin C, Muse S, Hontecillas R, Bassaganya- Riera J, Caudell DL, Shimp SK 3rd, Rylander MN, Zhang J, Li L, Reilly CM. Deletion of PPAR-g-y in immune cells enhances susceptibility to anti-glomerular basement membrane disease. Journal of Inflammation Research. 2010; 3:127-34.

22096362
2013

Chafin CB, Reilly CM. MicroRNAs implicated in the immunopathogenesis of lupus nephritis [review]. Clin Dev Immunol 2013; 2013:430239. PMID: 23983769.

23983769
2013

Puthiyaveetil AG, Okyere B, Reilly CM, Caudell D. Diverging in vitro antibody isotype switching preference in B-lymphocytes from C57BL/6 and FVB mice. In Vivo. 2013 Jan-Feb; 27(1):29-39. PMID: 23239849.

23239849
2013

Puthiyaveetil AG, Reilly CM, Pardee TS, Caudell DL. Non-homologous end joining mediated DNA repair is impaired in the NUP98-HOXD13 mouse model for myelodysplastic syndrome. Leuk. Res. 2013 Jan; 37(1):112-6. PMID: 23131583.

23131583
2013

Chafin CB, Regna NL, Dai R, Caudell DL, Reilly CM. MicroRNA-let-7a expression is increased in the mesangial cells of NZB/W mice and increases IL-6 production in vitro. Autoimmunity. 2013 Sep; 46(6):351-62. PMID: 24001203.

24001203
2013

Wong LL, Hirst SM, Pye QN, Reilly CM, Seal S, McGinnis JF. Catalytic nanoceria are preferentially retained in the rat retina and are not cytotoxic after intravitreal injection. PLoS One. 2013; 8(3):e58431. PMID: 23536794.

23536794
2013

Hirst SM, Karakoti A, Singh S, Self W, Tyler R, Seal S, Reilly CM. Bio-distribution and in vivo antioxidant effects of cerium oxide nanoparticles in mice. Environ Toxicol. 2013 Feb; 28(2): 107-18. PMID: 21640722.

21640722
2012

Puthiyaveetil AG, Heid B, Reilly CM, HogenEsch H, Caudell DL. A NUP98-HOXD13 leukemic fusion gene leads to impaired class switch recombination and antibody production. Exp Hematol. 2012 Aug; 40(8):622-33. PMID: 22613470.

22613470
2012

Shimp SK 3rd, Chafin CB, Regna NL, Hammond SE, Read MA, Caudell DL, Rylander M, Reilly CM. Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/lpr mouse model of systemic lupus erythematosus. Cell Mol Immunol. 2012 May; 9(3):255-66. PMID: 22543833.

22543833
2012

Shimp SK 3rd, Parson CD, Regna NL, Thomas AN, Chafin CB, Reilly CM, Nichole Rylander M. HSP90 inhibition by 17-DMAG reduces inflammation in J774 macrophages through suppression of Akt and nuclear factor-?B pathways. Inflamm. Res. 2012 May; 61(5):521-33. PMID: 22327510.

22327510
2011

Reilly CM, Regna N, Mishra N. HDAC inhibition in lupus models. Molecular Medicine Reports. 2011 May-Jun; 17(5-6): 417-25. PMID: 21327298.

21327298
2011

Yan K, Cao Q, Reilly CM, Young NL, Garcia BA, Mishra N. Histone deacetylase 9 deficiency protects against effector T cell-mediated systemic autoimmunity. The Journal of Biological Chemistry. 2011 Aug 19; 286(33):28833-43. PMID: 21708950.

21708950
2010

Peairs A, Dai R, Gan L, Shimp S, Rylander MN, Li L, Reilly CM. Epigallocatechin- 3-gallate (EGCG) attenuates inflammation in MRL/lpr mouse mesangial cells. Cellular & Molecular Immunology. 2010 Mar; 7(2):123-32. PMID: 20140007.

20140007